CHARACTERIZATION OF PEDIATRIC PATIENTS WITH URINARY TRACT INFECTION IN CHILDHOOD


Concurrent hypokalemic periodic paralysis and bipolar disorder

Primary periodic paralysis is a rare autosomal dominant disorder of ion-channel dysfunction, manifested by episodic flaccid paresis secondary to abnormal sarcolemma excitability.Membrane destabilization involving Na, K-ATPase has been hypothesized to be a biological etiology of the bipolar disorder (BD) and the mechanisms underlying lithium therapy

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Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans

ABSTRACT Regulated erroneous protein translation (adaptive mistranslation) increases proteome diversity and produces advantageous phenotypic variability in the human pathogen Candida albicans.It also increases fitness in the presence of fluconazole, but the underlying molecular mechanism is not understood.To address this question, we evolved hyperm

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